853050-49-4Relevant academic research and scientific papers
Cyclization of O-benzoyl-β-piperidinopropionamidoximes to form 5-phenyl-3-(β-piperidino)ethyl-1,2,4-oxadiazoles
Kayukova,Zhumadildaeva,Praliyev
, p. 2100 - 2105 (2002)
The reactions of β-piperidinopropionamidoxime with substituted benzoyl chlorides afforded O-benzoylation products, which underwent cyclization to form 5-phenyl-3-(β-piperidino)ethyl-1,2,4-oxadiazoles upon heating in dimethylformamide in the presence of molecular sieves at 60°C for 1 - 2.5 h. Heating of O-benzoyl-β-piperidinopropionamidoxime in dimethylformamide in the presence of K2CO3 at 85°C for 4 h afforded a mixture of 5-phenyl-3-(β-piperidino)ethyl-1,2,4-oxadiazole, benzoic acid, and N-(β-piperidino)ethylurea.
