853055-70-6Relevant academic research and scientific papers
N-Acridin-9-yl-butane-1,4-diamine derivatives: High-affinity ligands of the α2δ subunit of voltage gated calcium channels
Lim, Jongwon,Stock, Nicholas,Pracitto, Richard,Boueres, Julia K.,Munoz, Benito,Chaudhary, Ashok,Santini, Angelina M.,Orr, Karia,Schaffhauser, Herve,Bezverkov, Robert E.,Aiyar, Jayashree,Venkatraman, Shankar
, p. 1913 - 1916 (2004)
A series of N-acridin-9-yl-butane-1,4-diamines were found to be high-affinity ligands of the α2δ subunit of voltage gated calcium channels. The SAR studies of butane-1,4-diamine side chain resulted in the identification of compound 10 (IC5
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
Pinkerton, Anthony B.,Huang, Dehua,Cube, Rowena V.,Hutchinson, John H.,Struthers, Mary,Ayala, Julia M.,Vicario, Pasquale P.,Patel, Sima R.,Wisniewski, Thomas,DeMartino, Julie A.,Vernier, Jean-Michel
, p. 807 - 813 (2007/10/03)
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50/sub
PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN
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Page/Page column 30, (2010/02/11)
The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorde
