853067-10-4

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 583843-99-6 3'-C-(hydroxymethyl)-5'-O-tritylthymidine 
• 131607-35-7 3'-deoxy-3'-C-methylidene-5'-O-(triphenylmethyl)thymidine 

Downstream Products

• 853067-14-8 Toluene-4-sulfonic acid (2R,3R,5R)-3-azidomethyl-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 853067-17-1 1-{3a-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methyl]-hexahydro-furo[2,3-c]pyrrol-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 853067-12-6 1-((2R,4R,5R)-4-Azidomethyl-4-hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 878557-12-1 5-Methyl-1-((3R,4R,6R)-4-trityloxymethyl-1,5-dioxa-spiro[2.4]hept-6-yl)-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Adjustment of the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate enhances its binding affinity towards complementary strands

(Chemical Equation Presented) Bridge to the right angle: A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within the +sc orientation (see scheme), which improves duplex-forming a

Synthesis and properties of a novel bridged nucleic acid analogue, 5′-amino-3′,5′-BNA

An oligonucleotide P3′→ N5′ phosphoramidate (5′-amino-DNA) attracts much attention because of its potential for application to DNA sequencing; however, its ability to hybridize with complementary strands is low. To overcome this drawback of the 5′-amino-D