85313-33-3Relevant academic research and scientific papers
Backbone modifications of aromatic peptide nucleic acid (APNA) monomers and their hybridization properties with DNA and RNA
Fader,Boyd,Tsantrizos
, p. 3372 - 3379 (2007/10/03)
Aromatic peptide nucleic acid (APNA) monomers containing N-(2-aminobenzyl)-glycine, N-(2-aminobenzyl)-(R)- or -(S)-alanine, and N-(2-aminobenzyl)-β-alanine moieties as part of their backbone were synthesized. These novel analogues were incorporated as a single "point mutation" in PNA hexamers, and their physicochemical properties were investigated by UV thermal denaturation and CD experiments. Destabilization in triplex formation between the PNA-APNA chimeras and complementary DNA or RNA oligomers was observed, as compared to the PNA control. The APNA monomer composed of the N-(2-aminobenzyl)-glycine backbone led to the smallest decrease in the thermal stability of the triplexes formed with DNA and RNA, while maintaining selectivity for base-pairing recognition. Since the PNA-APNA chimeras are more lipophilic than the corresponding PNA homopolymers, these oligomers may also exhibit better cell membrane permeability properties.
Peptide Conformations, 22. - The Conformation of cyclo- in Crystal and Solution by X-ray Analysis and One- and Two-dimensional NMR Spectroscopy
Kessler, Horst,Schuck, Regina,Siegmeier, Rainer,Bats, Jan Willem,Fuess, Hartmut,Foerster, Hans
, p. 231 - 247 (2007/10/02)
The conformation of the cyclic tripeptide cyclo- (NB= o-Nitrobenzyl) was investigated by X-ray analysis and NMR spectroscopy.The backbone conformation is - according to X-ray analysis - a boat for crystals grown from methanol or chloroform.T
