85313-56-0

Upstream product

• 328-38-1 (R)-leucine 
• 85313-44-6 t-Bumeoc-L-Phe-OH 
• 15181-11-0 3, 5-di-tert-butyltoluene 
• 16225-26-6 3,5-di-tert-butylbenzoic acid 
• 64277-87-8 methyl 3,5-di(tert-butyl)benzoate 
• 85313-39-9 Fluorameisensaeure-<1-(3,5-di-tert-butylphenyl)-1-methylethyl>ester 
• 14665-97-5 2-(3,5-Di-tert-butylphenyl)-2-propanol 

Downstream Products

• 85313-58-2 t-Bumeoc-L-Phe-D-Leu-L-Arg-L-Phe-NH₂ 

Relevant academic research and scientific papers

The 1-(3,5-Di-tert-butylphenyl)-1-methylethoxycarbonyl (t-Bumeoc) Residue, a Protecting Group Cleavable under Extremely Mild Acidic Conditions

The synthesis of 1-(3,5-di-tert-butylphenyl)-1-methylethoxycarbonyl fluoride (8) and its reaction with selected amino acids as well as the 13C NMR spectroscopic characterization of t-Bumeoc derivatives are described.The new protecting group is cleavable under very mild acidic conditions.The kinetics of the cleavage is studied by high-performance liquid chromatography (HPLC).The utility of the t-Bumeoc compared to the Adpoc protecting group is demonstrated taking a derivative of the molluscan neuropeptide as an example.