85313-58-2

Basic information

• Product Name: L-Phenylalaninamide, N-[[1-[3,5-bis(1,1-dimethylethyl)phenyl]-1-methylethoxy]carbonyl]-L-phen ylalanyl-D-leucyl-L-arginyl-
• CAS NO: 85313-58-2
• Molecular Formula: C48H70N8O6
• Molecular Weight: 855.134
• Mol File: 85313-58-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Phenylalaninamide, N-[[1-[3,5-bis(1,1-dimethylethyl)phenyl]-1-methylethoxy]carbonyl]-L-phen ylalanyl-D-leucyl-L-arginyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalaninamide, N-[[1-[3,5-bis(1,1-dimethylethyl)phenyl]-1-methylethoxy]carbonyl]-L-phen ylalanyl-D-leucyl-L-arginyl-(85313-58-2)
• EPA Substance Registry System: L-Phenylalaninamide, N-[[1-[3,5-bis(1,1-dimethylethyl)phenyl]-1-methylethoxy]carbonyl]-L-phen ylalanyl-D-leucyl-L-arginyl-(85313-58-2)

Safety Data

• Hazardous Substances Data: 85313-58-2(Hazardous Substances Data)

Upstream product

• 16225-26-6 3,5-di-tert-butylbenzoic acid 
• 85313-44-6 t-Bumeoc-L-Phe-OH 
• 85313-39-9 Fluorameisensaeure-<1-(3,5-di-tert-butylphenyl)-1-methylethyl>ester 
• 14665-97-5 2-(3,5-Di-tert-butylphenyl)-2-propanol 
• 64277-87-8 methyl 3,5-di(tert-butyl)benzoate 
• 15181-11-0 3, 5-di-tert-butyltoluene 
• 2047-13-4 L-arginyl-L-phenylalanine 
• 85313-56-0 t-Bumeoc-L-Phe-D-Leu-OH 

Relevant articles and documents

The 1-(3,5-Di-tert-butylphenyl)-1-methylethoxycarbonyl (t-Bumeoc) Residue, a Protecting Group Cleavable under Extremely Mild Acidic Conditions

The synthesis of 1-(3,5-di-tert-butylphenyl)-1-methylethoxycarbonyl fluoride (8) and its reaction with selected amino acids as well as the 13C NMR spectroscopic characterization of t-Bumeoc derivatives are described.The new protecting group is cleavable under very mild acidic conditions.The kinetics of the cleavage is studied by high-performance liquid chromatography (HPLC).The utility of the t-Bumeoc compared to the Adpoc protecting group is demonstrated taking a derivative of the molluscan neuropeptide as an example.