853261-37-7

Upstream product

• 21240-37-9 4-[4-(4-hydroxybutyl)phenyl]butan-1-ol 
• 900186-21-2 4,4'-(1,4-phenylene)dibutyl dimesylate 
• 22339-61-3 γ-(p-succinylphenyl)butyric acid 
• 22339-62-4 4-[4-(3-carboxypropyl)phenyl]butyric acid 

Downstream Products

• 900186-19-8 6,6'-(1,4-phenylene)bis[2-(dimethylsulfanylidene)hexanal] 
• 900186-26-7 6,6'-(1,4-phenylene)bis[2-(methylthio)hexanal] 

Relevant academic research and scientific papers

Highly regioselective transformation of out/out-equatorial bis(formylmethano)[60]fullerenes: Construction of dissymmetric [60]fullerene-centered triads

Three kinds of out/out-equatorial bis(formylmethano)[60]fullerenes (1b-d) were obtained by the tether-directed bifunctionalization of [60]fullerene with bis(α-formylsulfonium ylide)s. The condensation of aromatic amines with 1b-d proceeded with an unexpec

Mono- and bis-thiazolium salts have potent antimalarial activity

Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC50 values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED50 ≤ 0.22 mg/kg), and low toxicity in mice infected by Plasmodium vinckei.