22339-61-3

Upstream product

• 108-30-5 succinic acid anhydride 
• 10031-93-3 ethyl 4-phenylbutyrate 

Downstream Products

• 6544-06-5 <12>paracyclophane 
• 2778-48-5 1,4-bis-(4-bromobutyl)benzene 
• 6337-65-1 4-[4-(3-methoxycarbonylpropyl)phenyl]butyric acid methyl ester 
• 134520-11-9 6,6'-p-phenylene-di-hexanoic acid 
• 882654-00-4 4,4'-(cis-cyclohexane-1,4-diyl)-di-butyric acid 
• 6337-63-9 4,4'-(trans-cyclohexane-1,4-diyl)-di-butyric acid dimethyl ester 
• 6337-63-9 4,4'-(cis-cyclohexane-1,4-diyl)-di-butyric acid dimethyl ester 
• 201138-69-4 6,6'-p-phenylene-di-hexanoic acid dimethyl ester 
• 343588-18-1 1,4-bis-(5,5-dicarboxy-pentyl)-benzene 
• 21240-37-9 4-[4-(4-hydroxybutyl)phenyl]butan-1-ol 
• 853261-37-7 4,4'-(1,4-phenylene)dibutyl diiodie 
• 22339-62-4 4-[4-(3-carboxypropyl)phenyl]butyric acid 

Relevant academic research and scientific papers

Mono- and bis-thiazolium salts have potent antimalarial activity

Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC50 values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED50 ≤ 0.22 mg/kg), and low toxicity in mice infected by Plasmodium vinckei.