853271-16-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(2-bromo-5-fluorophenyl)propan-2-ol is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Production:
BFP serves as an intermediate in the production of agrochemicals, playing a crucial role in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Fine Chemicals Production:
2-(2-bromo-5-fluorophenyl)propan-2-ol is utilized as an intermediate in the production of fine chemicals, which are essential in various industries, including cosmetics, fragrances, and specialty chemicals.
Used as a Reagent in Organic Synthesis:
BFP functions as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the synthesis of complex organic compounds.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(2-bromo-5-fluorophenyl)propan-2-ol has potential applications in the development of new therapeutic compounds, providing a foundation for the discovery of innovative treatments and medications.
It is important to handle 2-(2-bromo-5-fluorophenyl)propan-2-ol with care and in accordance with safety guidelines to mitigate any health and environmental risks associated with its use.

Upstream product

• 6942-39-8 methyl 2-bromo-5-fluorobenzoate 
• 75-16-1 methylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 

Downstream Products

• 1254981-98-0 1-benzyl-4-[4-fluoro-2-(1-hydroxy-1-methyl-ethyl)-phenyl]-4-hydroxypiperidine 
• 853270-98-1 4-fluoro-2-(1-methoxy-1-methylethyl)-1-vinylbenzene 
• 853271-20-2 4-fluoro-2-(1-methoxy-1-methylethyl)benzaldehyde 
• 853271-18-8 1-bromo-4-fluoro-2-(1-methoxy-1-methylethyl)benzene 

Relevant academic research and scientific papers

Benzoxaborole Catalyst for Site-Selective Modification of Polyols

The site-selective modification of polyols bearing several hydroxyl groups without the use of protecting groups remains a significant challenge in synthetic chemistry. To address this problem, novel benzoxaborole derivatives were designed as efficient catalysts for the highly site-selective and protecting-group-free modification of polyols. To identify the effective substituent groups enhancing the catalytic activity and selectivity, a series of benzoxaborole catalysts 1a–k were synthesized. In-depth analysis for the substituent effect revealed that 1i–k, bearing multiple electron-withdrawing fluoro- and trifluoromethyl groups, exhibited the greatest catalytic activity and selectivity. Moreover, 1i-catalyzed benzoylation, tosylation, benzylation, and glycosylation of various cis-1,2-diol derivatives proceeded with good yield and site-selective manner.

INHIBITORS OF THE MENIN-MLL INTERACTION

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Zirconocene-mediated and/or catalyzed unprecedented coupling reactions of alkoxymethyl-substituted styrene derivatives

Reactions of o-(alkoxymethyl)styrene derivatives with a stoichiometric amount of zirconocenebutene complex (zirconocene equivalent, "Cp 2Zr") brought about an insertion of the zirconocene species into a benzylic carbon-oxygen bond. The oxidative insertion of Cp2Zr to the benzylic carbon-oxygen bond is a result of sequential reactions: (i) formation of zirconacyclopropane by the ligand exchange with o-(alkoxymethyl)styrene, (ii) elimination of the alkoxy group through an aromatic conjugate system giving metalated o-quinodimethane species, and (iii) transfer of zirconium metal to the benzylic position. Through use of a catalytic amount of "Cp2Zr", however, unprecedented homo-coupling reactions (dimerization) of o-(alkoxymethyl)styrene derivatives occurred to give a tetracyclic compound. On the other hand, reactions of o-(1-alkoxyisopropyl) styrene derivatives gave rise to the analogous tetracyclic compounds regardless of the amount of "Cp2Zr" (stoichiometric or catalytic). Heterocoupling product between o-(1-alkoxyisopropyl)styrene and styrene congeners was obtained in high cis stereo- and regioselectivity by treating o-(1-alkoxyisopropyl)styrene derivatives with "Cp2Zr" in the presence of an excess amount of styrene derivatives.