853299-52-2

Basic information

• Product Name: ATH 686
• Synonyms: ATH 686;1-[4-(2-AMinopyriMidin-4-yloxy)phenyl]-3-[4-[(4-ethylpiperazin-1-yl)Methyl]-3-trifluoroMethylphenyl]urea
• CAS NO: 853299-52-2
• Molecular Formula: C₂₅H₂₈F₃N₇O₂
• Molecular Weight: 515.53
• Mol File: 853299-52-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ATH 686(CAS DataBase Reference)
• NIST Chemistry Reference: ATH 686(853299-52-2)
• EPA Substance Registry System: ATH 686(853299-52-2)

Safety Data

• Hazardous Substances Data: 853299-52-2(Hazardous Substances Data)

Upstream product

• 853298-46-1 4-(4-nitro-phenoxy)-pyrimidin-2-ylamine 
• 630125-92-7 N-[4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-2,2,2-trifluoro-acetamide 
• 54840-15-2 4-N-tert-butoxycarbonylaminophenol 
• 630125-91-6 4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenylamine 
• 417724-26-6 4-(4-amino-phenoxy)-pyrimidin-2-ylamine 
• 876322-73-5 4-amino-2-(trifluoromethyl)benzaldehyde 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 

Relevant articles and documents

Syntheses of a triad of Flt3 kinase inhibitors: From bench to pilot plant

We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent