876322-73-5

Usage

Uses

Used in Pharmaceutical Industry:
Benzaldehyde, 4-amino-2-(trifluoromethyl)is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. It contributes to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
Benzaldehyde, 4-amino-2-(trifluoromethyl)is utilized in the production of agrochemicals, specifically as a precursor in the synthesis of pesticides and other crop protection agents, enhancing their effectiveness and selectivity.
Used in Dye Production:
Benzaldehyde, 4-amino-2-(trifluoromethyl)is used as an intermediate in the manufacturing of dyes, contributing to the creation of a diverse range of colorants for various applications.
Used in Perfumery:
It serves as a building block in the production of perfumes, where its unique aromatic properties are harnessed to create distinct fragrances.
Used in Flavoring Agents:
Benzaldehyde, 4-amino-2-(trifluoromethyl)is used in the synthesis of flavoring agents, adding unique taste profiles to food and beverages.
Used in Organic Chemistry Research:
Benzaldehyde, 4-amino-2-(trifluoromethyl)is a versatile reagent in organic chemistry, used for various chemical transformations to produce a wide array of functionalized compounds, advancing the field of organic synthesis and material science.
Used in Biological and Pharmacological Research:
Due to its potential biological and pharmacological activities, this chemical is an interesting target for research and development, potentially leading to new discoveries and applications in medicine and biology.

Upstream product

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 859027-06-8 (4-nitro-2-(trifluoromethyl)phenyl)methanol 
• 320-37-6 4-nitro-2-(trifluoromethyl)benzoic acid 
• 50551-17-2 4-nitro-2-(trifluoromethyl)benzaldehyde 
• 98-16-8 3-trifluoromethylaniline 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 853299-52-2 1-[4-(2-aminopyrimidin-4-yloxy)phenyl]-3-[4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea 
• 853299-07-7 1-[4-(2-aminopyrimidine-4-yloxy)phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea 
• 630124-46-8 AST-487 
• 630125-91-6 4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenylamine 
• 900254-46-8 (4-amino-2-(trifluoromethyl)phenyl)methanol 
• 694499-26-8 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 1186206-79-0 ALW-II-41-27 
• 872332-67-7 3-amino-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 
• 872332-66-6 N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methyl-3-nitrobenzamide 

Relevant academic research and scientific papers

A Putative Single-Photon Emission CT Imaging Tracer for Erythropoietin-Producing Hepatocellular A2 Receptor

Erythropoietin-producing hepatocellular (Eph) receptors are receptor tyrosine kinases involved in cell-cell contact. The EphA2 receptor is associated with cancer proliferation and migration. Therefore, EphA2 receptor imaging has the potential for cancer d

Method for synthesizing 4- amino -2- trifluoromethyl cyanobenzene

The method 4 - comprises the following steps, dissolving m-aminotrifluorotoluene in a solvent :S1, and adding ethyl formate, into toluene, and adding acetic acid, to reflux to obtain 4 - amino-2-trifluoromethylbenzonitrile ;S2, and adding the 4 - amino - 2 2-trifluoromethyl cyanobenzaldehyde, into toluene through reflux reaction, to obtain 4 - amino - 2 2-trifluoromethyl cyanobenzonitrile in a ratio. The invention discloses S1 amino- 2 2-trifluoromethyl cyanobenzonitrile in the following processing step: Step 1:1-10, The reaction is mild and no special equipment 8%-10%, is required to be used, 50%-60%. The method comprises the following steps of: synthesizing ethyl formate and refluxing acetic acid; and synthesizing ethyl formate by adding the methyl formate to toluene and refluxing the acetic acid ethyl ester to prepare, amino. 2 2-trifluoromethylbenzonitrile.

Highly chemoselective intermolecular cross-benzoin reactions using an: Ad hoc designed novel N-heterocyclic carbene catalyst

The design of a novel N-heterocyclic carbene catalyst incorporating a bulky yet highly electron-deficient N-aryl substituent has allowed the development of an efficient protocol for the first highly chemoselective intermolecular benzoin condensations between two non-identical aromatic aldehydes.

PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF

Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-l-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.

Syntheses of a triad of Flt3 kinase inhibitors: From bench to pilot plant

We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent

Trifluoromethyl substituted benzamides as kinase inhibitors

The invention relates to trifluoromethyl substituted benzamide compounds of the formula I, pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases, especially of ephrin receptor kinases, and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.