85333-26-2

Basic information

• Product Name: 2-Amino-4-(benzyloxy)pyridine
• Synonyms: 2-Amino-4-(benzyloxy)pyridine;4-(Benzyloxy)pyridin-2-amine
• CAS NO: 85333-26-2
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol File: 85333-26-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 379.7 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: /
• Density: 1.180
• Vapor Pressure: 5.74E-06mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.76±0.11(Predicted)
• CAS DataBase Reference: 2-Amino-4-(benzyloxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-(benzyloxy)pyridine(85333-26-2)
• EPA Substance Registry System: 2-Amino-4-(benzyloxy)pyridine(85333-26-2)

Safety Data

• Hazardous Substances Data: 85333-26-2(Hazardous Substances Data)

Usage

General Description

2-Amino-4-(benzyloxy)pyridine is a chemical compound with the molecular formula C13H12N2O. It is a pyridine derivative that contains an amino group and a benzyloxy group attached to the pyridine ring. 2-Amino-4-(benzyloxy)pyridine is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It has also been studied for its potential therapeutic applications in the treatment of cancer and other diseases. 2-Amino-4-(benzyloxy)pyridine is an important intermediate in the production of various pharmaceuticals and fine chemicals.

InChI:InChI=1/C12H12N2O/c13-12-8-11(6-7-14-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H2,13,14)

Upstream product

• 182556-72-5 2-chloro-4-(benzyloxy)pyridine 
• 23056-36-2 2-chloro-4-nitropyridine 
• 34941-91-8 2-chloro-4-fluoropyridine 
• 26452-80-2 2,4-dichloropyridine 
• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 1184918-18-0 t-butyl(4-benzyloxypyridin-2-yl)amine 
• 2683-66-1 4-benzyloxypyridine-N-oxide 
• 100-51-6 benzyl alcohol 
• 1124-33-0 4-nitraminopyridine N-oxide 

Downstream Products

• 1415834-64-8 N-(4-benzyloxypyridin-2-yl)-2-(2,6-difluorophenyl)acetamide 
• 1415834-60-4 N-(4-benzyloxypyridin-2-yl)-3-phenylpropionamide 
• 1415834-59-1 N-(4-benzyloxypyridin-2-yl)-2-phenylacetamide 
• 1415834-62-6 N-(4-benzyloxypyridin-2-yl)-2-(4-fluorophenyl)acetamide 

Relevant articles and documents

6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS

The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.

ERBB RECEPTOR INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.

Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2)

Novel 4-substituted 2-pyridin-2-ylamides were developed using in-silico ligand-based drug design (LBDD) in an attempt to identify inhibitors of SH2-containing 5′-inositol phosphatase 2 (SHIP2), which is implicated in insulin-resistant type 2 diabetes. Among the compounds synthesized, N-[4-(4-chlorobenzyloxy)pyridin-2-yl]-2-(2,6-difluorophenyl)- acetamide (CPDA, 4a) was identified as a potent SHIP2 inhibitor. CPDA was found to enhance in vitro insulin signaling through the Akt pathway more efficiently than the previously reported SHIP2 inhibitor AS1949490, and ameliorated abnormal glucose metabolism in diabetic (db/db) mice.