945988-90-9

Upstream product

• 942947-94-6 5-bromo-4-chloro-pyridin-2-ylamine 
• 100-51-6 benzyl alcohol 
• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 182556-72-5 2-chloro-4-(benzyloxy)pyridine 
• 85333-26-2 4-(benzyloxy)pyridin-2-amine 

Downstream Products

• 945988-91-0 1-benzoyl-3-(4-(benzyloxy)-5-bromopyridin-2-yl)thiourea 
• 945988-92-1 1-(4-(benzyloxy)-5-bromopyridin-2-yl)thiourea 
• 945988-93-2 4-(benzyloxy)-5-bromo-N-(4-phenethylthiazol-2-yl)pyridin-2-amine 
• 945988-95-4 5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-ol hydrochloride 

Relevant academic research and scientific papers

IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

This invention relates to Imidazo[l,2-a]pyridinyl Derivatives of formula (I), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.

GLUCOKINASE ACTIVATORS

Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase. (Formula I) wherein R2, L, Z, Y, G and R1 are as defined in the claims.