85336-82-9

Upstream product

• 20968-04-1 2,2’-bis(4-(chloro)phenyl)acetonitrile 
• 85078-25-7 1,1-bis-(4-chloro-phenyl)-2-nitro-ethane 
• 52234-91-0 2,2-bis-(4-chloro-phenyl)acetamide 
• 2642-81-1 1,1-bis(p-chlorophenyl)ethene 
• 83-05-6 bis(4'-chlorophenyl)acetic acid 

Downstream Products

• 102006-68-8 isonicotinic acid-[2,2-bis-(4-chloro-phenyl)-ethylamide] 
• 101876-76-0 [2,2-bis-(4-chloro-phenyl)-ethyl]-carbamic acid ethyl ester 
• 857530-81-5 2-(4-chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethylamine 
• 383888-73-1 (2R,3R,4S,5S)-4-(benzoyloxy)-2-(6-{[2,2-bis(4-chlorophenyl)ethyl]amino}-2-iodo-9H-purin-9-yl)-5-[(ethylamino)carbonyl]tetrahydro-3-furanyl benzoate 
• 90552-79-7 2,2'-{[2,2-Bis(4-chlorophenyl)ethyl]imino}bis{ethanol} 
• 98383-60-9 N₆-(2,2-Di(4-chlorophenyl)ethyl)adenosine 
• 87519-88-8 (6R,10bR)-9-Chloro-6-(4-chloro-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline 
• 87519-90-2 9-chloro-6α-(4-chlorophenyl)-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinoline 
• 87519-59-3 (6R,10bS)-9-Chloro-6-(4-chloro-phenyl)-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one 
• 87519-58-2 (6S,10bS)-9-Chloro-6-(4-chloro-phenyl)-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one 

Relevant academic research and scientific papers

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Identification of inhibitors of protein kinase B using fragment-based lead discovery

Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 μM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand effi

NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS

This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy an

SULFONAMIDE COMPOUNDS

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.