83-05-6

Usage

Uses

Used in Pharmaceutical Industry:
4,4'-DDA is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, including herbicides and other agrochemicals. Its unique structure allows it to be a key component in the development of new drugs and chemical products.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4,4'-DDA serves as a building block for the creation of more complex organic molecules. Its reactivity and functional groups make it a valuable precursor in the synthesis of various organic compounds, contributing to the advancement of chemical research and development.
Used in Research and Development:
4,4'-DDA is utilized in research and development settings to study the properties and behavior of organochlorine compounds. Its unique structure and reactivity make it an interesting subject for scientific investigations, potentially leading to new discoveries and applications in various fields.

Safety Profile

Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. When heated todecomposition it emits toxic fumes of Cl-.

InChI:InChI=1/C14H10Cl2O2/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8,13H,(H,17,18)

Upstream product

• 72-55-9 1,1-bis(4-chlorophenyl)-2,2-dichloroethylene 
• 141-52-6 sodium ethanolate 
• 39179-78-7 C₂₇H₁₉BrCl₂ 
• 94377-74-9 Bis-<4-chlor-phenyl>-malonsaeure-diaethylester 
• 39502-40-4 2,2-bis-(4-chloro-phenyl)-acetohydroximoyl chloride 
• 50-29-3 p,p'-DDT 
• 7440-44-0 pyrographite 
• 34220-01-4 di-(4-chlorophenyl)iodonium chloride 
• 52207-56-4 1-chloro-4-iodosylbenzene 
• 16825-76-6 1-iodyl-4-chlorobenzene 
• 10304-75-3 4-chloro(dichloroiodo)benzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 39179-73-2 C₂₇H₂₀Cl₂ 
• 6306-46-3 1-[bromo(4-chlorophenyl)methyl]-4-chlorobenzene 

Downstream Products

• 5359-38-6 methyl 2,2-bis(4-chlorophenyl) acetate 
• 30738-51-3 ethyl 2,2-bis(4-chlorophenyl)acetate 
• 101-76-8 4,4'-dichlorodiphenylmethane 
• 2642-82-2 2,2-bis(p-chlorophenyl)ethanol 
• 68668-89-3 2,2-bis(4-chlorophenyl)acetyl chloride 
• 33406-61-0 bis(4-chloro-3,5-dinitrophenyl)methanone 
• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 
• 1208553-14-3 C₁₇H₁₂Cl₂N₂OS 
• 3305-00-8 2-acetoxy-1,1-bis-(4-chloro-phenyl)-ethane 
• 92907-46-5 1,1-bis-(4-chloro-phenyl)-acetone semicarbazone 
• 6941-84-0 1,1-bis-(4-chloro-phenyl)-acetone oxime 
• 55525-14-9 1,1-bis(4-chlorophenyl)propan-2-one 
• 101876-76-0 [2,2-bis-(4-chloro-phenyl)-ethyl]-carbamic acid ethyl ester 
• 103037-17-8 tetrakis-(4-chloro-phenyl)-succinonitrile 

Relevant academic research and scientific papers

Metal-Free Hydrosilylation of Ketenes with Silicon Electrophiles: Access to Fully Substituted Aldehyde-Derived Silyl Enol Ethers

Little-explored hydrosilylation of ketenes promoted by main-group catalysts is reported. The boron Lewis acid tris(pentafluorophenyl)borane accelerates the slow uncatalyzed reaction of ketenes and hydrosilanes, thereby providing a convenient access to the new class of β,β-di- and β-monoaryl-substituted aldehyde-derived silyl enol ethers. Yields are moderate to high, and Z configuration is preferred. The corresponding silyl bis-enol ethers are also available when using dihydrosilanes. The related trityl-cation-initiated hydrosilylation involving self-regeneration of silylium ions is far less effective.

Rh-Catalyzed annulations of: N -methoxybenzamides with ketenimines: Synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties

Rhodium-catalyzed C-H activation/annulation reactions of ketenimines with N-methoxybenzamides furnished 3-aminoisoindolin-1-ones and 3-(diarylmethylene)isoindolin-1-ones. The synthesized 3-(diarylmethylene)isoindolin-1-ones exhibited aggregation induced emissions in aqueous tetrahydrofuran solution and strong green-yellow emissions in solids.

Taming of superacids: PVP-triflic acid as an effective solid triflic acid equivalent for Friedel-Crafts hydroxyalkylation and acylation

The application of poly(4-vinylpyridine) supported trifluoromethanesulfonic acid (PVP-TfOH, 1:10) as a convenient solid superacid catalyst system in Friedel-Crafts reactions is described. In the presence of PVP-TfOH, one pot solvent-free synthesis of a wide variety of diarylacetic acid derivatives was achieved by Friedel-Crafts hydroxyalkylation reaction of glyoxylic acid with arenes under mild conditions. Acylation of both activated and deactivated aromatic compounds with acetyl chloride was also achieved using PVP-TfOH complex under solvent-free conditions at room temperature. As the polymer supported triflic acid was found to be a very efficient and an easy-to-handle solid acid, it can be a useful addition to environmentally more adaptable strong acid catalyst systems.

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions.

Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit

Melanin-concentrating hormone (MCH) is involved in the regulation of feeding, water balance, energy metabolism, general arousal and attention state, memory, cognitive functions, and psychiatric disorders. Herein, two new chemical series exemplified by N-[5-(1-{3-[2,2-bis-(4-fluoro-phenyl)-acetylamino]- propyl}-piperidin-4-yl)-2,4-difluoro-phenyl]-isobutyramide (SNAP 102739, 5m) and N-[3-(1-{3-[(S)-2-(4-fluorophenyl)-propionylamino]-propyl}-piperidin-4-yl)-4- methylphenyl]-isobutyramide ((S)-6b) are reported. These compounds were designed to improve the pharmacokinetic properties of the high-throughput screening lead compound 1 (SNAP 7941). The MCH1 receptor antagonists 5m and (S)-6b show reasonable pharmacokinetic profiles (rat bioavailability = 48 and 81%, respectively). Compounds 5m and (S)-6b demonstrated the inhibition of a centrally administered MCH-evoked drinking effect, and compound 5m exhibited oral in vivo efficacy in the rat social interaction model of anxiety, with a minimum effective dose = 0.3 mg/kg.

N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents

The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, STR1 wherein X and Y are oxygen, sulfur, or (CR'R")n wherein n is 1 to 4; R is hydrogen, alkyl, or benzyl; R1 and R2 are phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, an alkyl chain, adamantyl, or a cycloalkyl group.

CARBOXYLATION OF ALCOHOLS WITH CARBON MONOXIDE SUPERSATURATED IN STRONG ACID. FACILE SYNTHESIS OF 2,2-BIS(4-HALOPHENYL)ACETIC, -PROPIONIC, AND RELATED ACIDS

Using 97percent H2SO4 supersaturated with carbon monoxide, bis(4-halophenyl)methanols, 1,1-bis(4-halophenyl)ethanols and related alcohols were transformed to the carboxylic acids in 60-95percent yields.

Aralkanamidophenyl compounds

This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.

Arylalkylaminobenzoic acids

This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.