857530-81-5Relevant academic research and scientific papers
PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
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, (2010/07/08)
The invention provides a combination comprising an ancillary compound (e.g. one, two or more ancillary compounds) and a compound of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing f
Identification of inhibitors of protein kinase B using fragment-based lead discovery
Saxty, Gordon,Woodhead, Steven J.,Berdini, Valerio,Davies, Thomas G.,Verdonk, Marcel L.,Wyatt, Paul G.,Boyle, Robert G.,Barford, David,Downham, Robert,Garrett, Michelle D.,Carr, Robin A.
, p. 2293 - 2296 (2008/02/05)
Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 μM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand effi
PHARMACEUTICAL COMPOUNDS
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Page/Page column 82-83, (2010/11/25)
The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length
