853400-76-7

Usage

Uses

Used in Pharmaceutical Industry:
L-Glutamic acid, glycyl-2-methyl-L-prolylis used as a building block for peptides and proteins for the development of pharmaceuticals, leveraging its dipeptide structure to create novel therapeutic agents.
Used in Biotechnology:
L-Glutamic acid, glycyl-2-methyl-L-prolylis used as a component in biotechnological applications, potentially contributing to the advancement of peptide-based therapies and diagnostic tools.
Used in Food Science:
L-Glutamic acid, glycyl-2-methyl-L-prolylis used as a flavor enhancer in the food industry, capitalizing on the taste-modifying properties of L-glutamic acid to improve the overall flavor profile of various food products.

Upstream product

• 123053-48-5 (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride 
• 103336-06-7 N-(tert-butoxycarbonyl)-2-methyl-L-proline 
• 2768-50-5 dibenzyl L-glutamate 
• 853400-82-5 (S)-2-[((S)-2-Methyl-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid dibenzyl ester 
• 147-85-3 L-proline 
• 220060-08-2 methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride 
• 220200-88-4 (3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one 
• 118916-60-2 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 
• 869001-94-5 dibenzyl N-benzyloxycarbonyl-glycyl-L-2-methylprolyl-L-glutamate 
• 869001-86-5 N-benzyloxycarbonyl-glycyl-L-2-methylproline 
• 847952-40-3 (S)-methyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)-2-methylpyrrolidine-2-carboxylate 

Relevant academic research and scientific papers

COMPOSITIONS OF TROFINETIDE

This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID

This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methyIprolyl-glutamic acid (G-2-MePE) and analogs thereof. Autism Spectrum Disorders include Autism, Autistic Disorder, Asperger Syndro

TREATMENT OF AUTISM SPECTRUM DISORDERES USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID

This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methylprolyl-glutamic acid (G-2-MePE) and analogs thereof. Autism Spectrum Disorders include Autism, Autistic Disorder, Asperger Syndro

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): Synthesis and structure-activity relationships

A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role

Synthesis of proline-modified analogues of the neuroprotective agent glycyl-L-prolyl-glutamic acid (GPE)

The synthesis of ten proline-modified analogues of the neuroprotective tripeptide GPE is described. Five of the analogues incorporate a proline residue with a hydrophobic group at C-2 and two further analogues have this side chain locked into a spirolactam ring system. The pyrrolidine ring was also modified by replacing the γ-CH2 group with sulfur and/or incorporation of two methyl groups at C-5.