85345-79-5Relevant academic research and scientific papers
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors
Sheng, Rong,Lin, Xiao,Li, Jingya,Jiang, Yanke,Shang, Zhicai,Hu, Yongzhou
, p. 3834 - 3837 (2007/10/03)
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.
Alkylative Amination of Non-enolizable Aldehydes with Alkyl(dialkylamino)titanium Derivatives
Seebach, Dieter,Schiess, Martin
, p. 2598 - 2602 (2007/10/02)
The readily available tris(diethylamino)methyltitanium and related compounds (see 1 in Scheme 2) react with non-enolizable aldehydes to give tertiary amines 2; these amines result from direct replacement of the carbonyl O-atom by an alkyl and an amino group (Scheme 3).A tentative mechanism is proposed, according to which the amino group is transferred to the carbonyl C-atom prior to the alkyl group (Scheme 4).
