853748-83-1Relevant articles and documents
Kinetic resolution of propargylic alcohols catalyzed by benzotetramisole
Birman, Vladimir B.,Guo, Lei
, p. 4859 - 4861 (2006)
(Chemical Equation Presented) Kinetic resolution of variously substituted secondary propargylic alcohols catalyzed by benzotetramisole (BTM) proceeds with selectivity factors up to 32, the highest ever achieved with nonenzymatic catalysts for this class o
Enantioselective and regioselective nickel-catalyzed multicomponent coupling of chiral allenes, aromatic aldehydes, and silanes
Ng, Sze-Sze,Jamison, Timothy F.
, p. 11405 - 11417 (2007/10/03)
A detailed account of the development of a recently developed, nickel-catalyzed multicomponent coupling of chiral allenes, aromatic aldehydes, and silanes is described. The axial chirality of the allene is transferred completely to the product, a trisubstituted Z-allylic alcohol protected as a silyl ether. A very high preference for sp rather than sp2 coupling is observed, and differentially substituted allenes undergo highly site-selective coupling. These transformations represent the first enantioselective multi-component coupling processes of allenes.
Highly enantioselective and regioselective nickel-catalyzed coupling of allenes, aldehydes, and silanes
Ng, Sze-Sze,Jamison, Timothy F.
, p. 7320 - 7321 (2007/10/03)
A complex derived from Ni(cod)2 and NHC-IPr catalyzes a three-component coupling reaction involving allenes, aldehydes, and organosilanes and transfers the axial chirality of the allene to a stereogenic center in the product with very high fide
