853783-20-7

Basic information

• Product Name: N⁴-benzyloxycarbonyl-N⁸-tert-butoxycarbonylspermidine
• Synonyms: N⁴-benzyloxycarbonyl-N⁸-tert-butoxycarbonylspermidine
• CAS NO: 853783-20-7
• Molecular Weight: 379.5
• Mol File: 853783-20-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N⁴-benzyloxycarbonyl-N⁸-tert-butoxycarbonylspermidine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁴-benzyloxycarbonyl-N⁸-tert-butoxycarbonylspermidine(853783-20-7)
• EPA Substance Registry System: N⁴-benzyloxycarbonyl-N⁸-tert-butoxycarbonylspermidine(853783-20-7)

Safety Data

• Hazardous Substances Data: 853783-20-7(Hazardous Substances Data)

Upstream product

• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 501-53-1 benzyl chloroformate 
• 68076-40-4 N¹-tert-butoxycarbonyl-N⁴-(2-cyanoethyl)-1,4-butanediamine 
• 853783-18-3 N¹-benzyloxycarbonyl-N⁴-tert-butoxycarbonyl-N¹-(2-cyanoethyl)-1,4-butanediamine 

Downstream Products

• 113283-99-1 N⁴-benzyloxycarbonyl-N¹,N⁸-di-tert-butoxycarbonylspermidine 
• 1375180-11-2 C₄₁H₄₈N₄O₅ 
• 1375180-12-3 C₆₄H₆₈N₄O₈ 
• 1375180-15-6 benzyl 4-(3-(3,4-bis(benzyloxy)phenyl)-N-(3-aminopropyl)propanamido)butyl(3-(3-(3,4-bis(benzyloxy)phenyl)propanamido)propyl)carbamate 
• 1375179-78-4 kukoamine B malate 
• 1375179-80-8 kukoamine B succinate 
• 1375179-82-0 kukoamine B lactate 
• 1375179-88-6 kukoamine B glutamate 
• 1375179-93-3 kukoamine B sulfate 
• 1375179-96-6 kukoamine B maleate 
• 1375179-97-7 kukoamine B aspartate 
• 1375180-00-9 kukoamine B phosphate 
• 1375180-08-7 C₄₃H₅₃N₃O₇ 
• 97628-87-0 benzyl (4-aminobutyl)(3-(((benzyloxy)carbonyl)amino)propyl)carbamate 

Relevant articles and documents

The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate

The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.

SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF

Provided are salts of kukoamine B, their preparation method and their use in preventing and treating sepsis diseases.

Efficient synthesis of orthogonally protected spermidine and norspermidine derivatives

Several orthogonally protected spermidine and norspermidine derivatives have been synthesized via cyanoethylation of monoprotected 1,4-butanediamine (putrescine) or 1,3-propanediamine followed by protection of their secondary amino groups and final reduct