85386-18-1Relevant academic research and scientific papers
NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS
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Page/Page column 48, (2011/04/14)
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4,5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cynanide
Yamanaka, Hiroshi,Sakamoto, Takao,Nishimura, Sumiko,Sagi, Mataichi
, p. 3119 - 3126 (2007/10/02)
The site-selectivity in the modified Reissert-Henze reaction of 5-substituted and 4,5-disubstituted pyrimidine 1-oxides with trimethylsilyl cyanide was examined.The reaction of 5-substituted 4-methoxypyrimidine 1-oxides with trimethylsilyl cyanide gave exclusively 2-pyrimidinecarbonitriles in good yields without exception.On the other hand, the other 5-substituted and 4,5-disubstituted pyrimidine 1-oxides gave mainly 6-pyrimidinecarbonitriles.Keywords--site-selectivity; pyrimidine N-oxide; trimethylsilyl cyanide; Reissert-Henze reasction; pyrimidinecarbonitrile
SYNTHESIS OF 5-ARYLPYRIMIDINE-2-CARBOXYLIC ACIDS AND THE LIQUID-CRYSTAL CHARACTERISTICS OF THEIR ARYL ESTERS
Mikhaleva, M. A.,Kolesnichenko, G. A.,Rubina, K. I.,Gol'dberg, Yu. Sh.,Savel'ev, V. A.,et al.
, p. 310 - 318 (2007/10/02)
5-Arylpyrimidine-2-carboxylic acids were synthesized by the hydrolysis of 5-aryl-2-cyanopyrimidines and the oxidation of 5-aryl-2-styrylpyrimidines under the conditions of phase-transfer catalysis.The aryl esters of the acids were obtained, and their liqu
