85390-46-1

Upstream product

• 39919-84-1 1-benzyl-4-vinylazetidin-2-one 
• 86694-80-6 ethyl 4-oxo-1-(phenylmethyl)-2-azetidinecarboxylate 
• 337522-48-2 1-benzyl-4-(tert-butyldimethylsilyloxymethyl)azetidin-2-one 
• 56598-99-3 diethyl 2-(benzylamino)malonate hydrochloride 
• 86694-78-2 diethyl N-benzyl-N-(chloroacetyl)aminomalonate 
• 16940-66-2 sodium tetrahydroborate 
• 78159-38-3 1-Benzyl-4-oxo-azetidine-2-carboxylic acid methyl ester 
• 86694-79-3 diethyl 1-benzyl-4-oxoazetidine-2,2-dicarboxylate 

Downstream Products

• 86694-81-7 1-benzyl-4-(mesyloxymethyl)-2-azetidinone 
• 76144-17-7 (4R) N-Benzyl-4-methoxycarbonylmethyl-azetidin-2-one 
• 80974-44-3 (S)-N-benzyl-4-carboxymethyl-2-azetidinone 
• 1613229-15-4 C₁₂H₁₄N₂O₂ 
• 1613229-02-9 C₁₂H₁₄N₂O₂ 
• 1613228-93-5 1-benzyl-4-cyanomethyl-β-lactam 
• 85390-48-3 1-Benzyl-4-(iodomethyl)azetidin-2-one 
• 85390-58-5 but-3-enoic acid benzylamide 
• 89232-30-4 (2E)-N-benzylbut-2-enamide 
• 4391-83-7 1-benzyl-4-methylazetidinone 
• 85390-47-2 1-Benzyl-4-(p-tosyloxymethyl)azetidin-2-one 

Relevant academic research and scientific papers

Efficient synthesis of highly enantiopure β-lactam derivatives from biocatalytic transformations of amides and nitriles

Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial strain, under mild conditions, kinetic resolution of racemic amides provides an efficient and scalable route to highly enantioenriched R-4-carboxymethyl-β-la

Protecting group migration in the chemistry of 1-t-butyldimethylsilyl-4-hydroxymethyl-2-azetidinone

The alkoxide anion derived from 1-t-butyldimethylsilyl-4-hydroxymethyl-2-azetidinone (1) rearranged at -78°C into amide anion by N-O migration of the silyl protecting group. The occurrence of this intermediate was proved by quenching with benzyl bromide and phenethyl chloroformate, giving respectively N-benzyl (4) and N-(phenethyloxycarbonyl) (6) derivatives of 4-(t-butyldimethylsilyloxy)methyl-2-azetidinone.

Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group

The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) STR1 wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and Y' represents a group of the formula --COOZ or --CH2 M, in which Z is lower alkyl and M is hydroxyl, halogen, cyano or a group of the formula --O--SO2 R2, in which R2 is lower alkyl or aryl, with the proviso that if R' is phenyl, Y' cannot stand for the group --COOC2 H5. The invention further relates to a process for the preparation of compounds of the general formula (IV) STR2 in which R and Y are identical with R' and Y', respectively, except the proviso. According to a further aspect of the invention there are provided pharmaceutical compositions, first of all with antihypoxic activity, comprising compounds of the general formula (IVa) as active ingredient.