86694-78-2

Upstream product

• 56598-99-3 diethyl 2-(benzylamino)malonate hydrochloride 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 86694-79-3 diethyl 1-benzyl-4-oxoazetidine-2,2-dicarboxylate 
• 86694-81-7 1-benzyl-4-(mesyloxymethyl)-2-azetidinone 
• 86694-80-6 ethyl 4-oxo-1-(phenylmethyl)-2-azetidinecarboxylate 
• 85390-46-1 1-Benzyl-4-(hydroxymethyl)azetidin-2-one 

Relevant academic research and scientific papers

Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group

The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) STR1 wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and Y' represents a group of the formula --COOZ or --CH2 M, in which Z is lower alkyl and M is hydroxyl, halogen, cyano or a group of the formula --O--SO2 R2, in which R2 is lower alkyl or aryl, with the proviso that if R' is phenyl, Y' cannot stand for the group --COOC2 H5. The invention further relates to a process for the preparation of compounds of the general formula (IV) STR2 in which R and Y are identical with R' and Y', respectively, except the proviso. According to a further aspect of the invention there are provided pharmaceutical compositions, first of all with antihypoxic activity, comprising compounds of the general formula (IVa) as active ingredient.