853917-06-3Relevant academic research and scientific papers
Convenient synthesis of an isoxazole compound, KRIBB3, as an anticancer agent
Lee, Hyeong Kyu,Yun, Eunju,Min, Ji Hye,Yoon, Kab Seog,Choung, Dong-Ho,Lee, Sangku
, p. 1890 - 1894 (2012/06/04)
A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents a
Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor
Lee, Sangku,Kim, Jae Nyoung,Lee, Hyeong Kyu,Yoon, Kab Seog,Shin, Ki Deok,Kwon, Byoung-Mog,Han, Dong Cho
, p. 977 - 979 (2011/03/21)
A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.
NEW DIARYL-ISOXAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME FOR THE PREVENTION AND THE TREATMENT OF CANCERS
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, (2010/11/25)
The present invention relates to new diaryl-isoxazole derivatives, and pharmaceutical compositions containing the same as an effective ingredient for the prevention and the treatment of cancers. Diaryl-isoxazole derivatives of the present invention inhibi
Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers
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Page/Page column 4-5, (2010/02/12)
The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of b
