853927-76-1

Basic information

• Product Name: 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-carboxaldehyde
• Synonyms: 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-carboxaldehyde
• CAS NO: 853927-76-1
• Molecular Weight: 296.279
• Mol File: 853927-76-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-carboxaldehyde(853927-76-1)
• EPA Substance Registry System: 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-carboxaldehyde(853927-76-1)

Safety Data

• Hazardous Substances Data: 853927-76-1(Hazardous Substances Data)

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 487-49-0 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone 
• 100-97-0 hexamethylenetetramine 
• 485-72-3 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on 
• 64-19-7 acetic acid 

Downstream Products

• 288266-76-2 7-acetoxy-3-(4-acetoxy-phenyl)-8-methyl-chromen-4-one 
• 139256-08-9 7-hydroxy-3-(4-hydroxyphenyl)-8-methyl-4H-chromen-4-one 
• 116718-51-5 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one 

Relevant articles and documents

Novel daidzein analogs and their in vitro anti-influenza activities

A series of novel isoflavonoids were synthesized based on structural modifications of daidzein, an active ingredient of traditional Chinese medicine (TCM) and evaluated for their anti-influenza activity, in vitro, against H1N1 Tamiflu-resistant (H1N1 TR) virus in the MDCK cell line. Among them, 4-oxo-4H-1-benzopyran-8-carbaldehydes 11a-11g were most promising, and they demonstrated better activities and selectivities comparable to those the reference ribarivin, a nucleoside antiviral agent. 3-(4-Bromophenyl)-7-hydroxy-4-oxo-4H-1-benzopyran-8-carboxaldehyde (11c) displayed the best inhibitory activity (EC50, 29.0 μM) and selectivity index (SI>10.3). Analysis of the structure￡activity relationships (SAR) indicated that both the non-naturally-occurring Br-substituted B-ring and appropriate CHO and OH groups on the A-ring might be critical for the activity and selectivity against H1N1 TR influenza viruses.