85393-37-9

Upstream product

• 121-44-8 triethylamine 
• 103309-63-3 Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 15715-58-9 triethylamine carbonate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 

Downstream Products

• 127383-29-3 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,5-dimethoxy-2,5-dihydro-furan-2-ylmethyl ester 
• 75251-83-1 5'-O-dimethoxytritylthymidylyl-(3',5')-(o-chlorophenyl)-thymidylyl-3'-β-cyanoethyl(o-chlorophenyl)phosphate 
• 138406-52-7 C₅₂H₅₃Cl₄N₅O₁₇P₂ 
• 151322-50-8 C₆₀H₆₁ClN₉O₁₅P 
• 259185-50-7 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester 
• 138406-54-9 C₂₆H₂₉ClN₄O₁₄P₂ 
• 138406-53-8 C₂₈H₃₀Cl₄N₄O₁₄P₂ 
• 138406-59-4 C₂₈H₃₂Cl₄N₄O₁₅P₂ 
• 138406-58-3 C₃₁H₃₅Cl₄N₅O₁₅P₂ 
• 138660-89-6 C₃₆H₄₁ClN₆O₁₈P₂ 

Relevant academic research and scientific papers

Improved synthesis of trinucleotide phosphoramidites and generation of randomized oligonucleotide libraries

A new method to produce a set of 20 high quality trinucleotide phosphoramidites on a 5-10 g scale each was developed. The procedure starts with condensation reactions of P-components with N-acyl nucleosides, bearing the 3′-hydroxyl function protected with 2-azidomethylbenzoyl, to give fully protected dinucleoside phosphates 13. Upon cleavage of dimethoxytrityl group from 13, dinucleoside phosphates 16 are initially transformed into trinucleoside diphosphates 19 and then the 2-azidomethylbenzoyl is selectively removed under neutral conditions to generate trinucleoside diphosphates 5 in excellent yield. Subsequent 3′-phosphitylation affords target trinucleotide phosphoramidites 7. When mutagenic oligonucleotides are synthesized employing mixtures of building blocks 7 as well as following the new synthetic protocol, representative oligonucleotide libraries are generated in good yields. Copyright Taylor & Francis Group, LLC.

RIBONUCLEIC ACID COMPOUND AND METHOD OF LIQUID-PHASE SYNTHESIS OF OLIGONUCLEIC ACID COMPOUND

A novel phosphotriesterified ribonucleic acid compound which is important for liquid-phase synthesis of oligo-RNA is provided. Examples of the ribonucleic acid compound of the invention may include ribonucleic acid compounds represented by the following general formula: (wherein B represents adenine, guanine, cytosine or uracil or a modified form thereof; R21 represents aryl which may be substituted or a monocyclic or bicyclic heterocyclic group which may be substituted; R20 represents H or alkyl which may be substituted; and R1 represents a protecting group which can be removed at 90% or more at a temperature in the range from 0°C to 60°C under acidic conditions at a pH value from 2 to 4 within 24 hours).

Straightforward synthesis of lipophilic thymidine glucopyranosyl monophosphates as models for a drug delivery system across cellular membranes

O-methyl (3'-6) and (5'-6) thymidinyl gluco- and mannopyranosides and (3'-6) thymidinyl glucofuranose can be synthesised in excellent yields by applying the phosphotriester method. The lipophilic phosphotriesters thus obtained are designed as carriers of nucleoside drugs across cellular membranes.