75251-83-1

Upstream product

• 85393-37-9 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt 
• 80817-40-9 2'-deoxythymidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate 
• 80817-37-4 5'-O-(dimethoxytrityl)thymidine 3'-(o-chlorophenyl β-cyanoethyl phosphate) 
• 80817-46-5 bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 
• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 81196-20-5 2-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate 
• 76958-58-2 [1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 85240-04-6 5'-O-dimethoxytritylthymidylyl-(3',5')-(o-chlorophenyl)-thymidylyl-3'-(o-chlorophenyl)phosphate 

Relevant academic research and scientific papers

NUCLEOSIDES AND NUCLEOTIDES. PART 27. SOLID PHASE SYNTHESIS OF A TRIDECANUCLEOSIDE DODECAPHOSPHATE CONTAINING THE UNNATURAL BASE 4-AMINO-2(1H)-PYRIDINONE AND OF AN OCTANUCLEOSIDE HEPTAPHOSPHATE FOR THE DETERMINATION OF THE DNA-POLYMERASE SPECIFICITY

The tridecanucleoside dodecaphosphate d-(T-T-Z-C-G-T-C-A-A-A-A-T-C) incorporating the modified nucleoside 4-amino-1-(2'-deoxy-β-ribofuranosyl)-2(1H)-pyridone (Zd, 1) and the octanucleoside heptaphosphate d(G-A-T-T-T-T-G-A) were synthesized by the solid-phase method using the triester method.The carrier material was a copolymer consisting of styrene with 1 percent divinylbenzene.

Chemical Synthesis of 80-mer Thymidylic Acid

Chemical synthesis of long-chain oligodeoxyribonucleotides was studied by the method of block condensation in a liquid phase.A method for elongating the chain and the synthesis of oligothymidylic acids up to 80-mer are dscribed.

Improved Synthesis of Oligodeoxyribonucleotides by Solid-Phase Phosphotriester Method Utilizing O6--2'-deoxyguanosine Derivatives

The synthesis of oligodeoxyribonucleotides on a cross-linked polystyrene solid support utilizing stable mono- and dinucleotide phosphotriester building blocks is presented.The use of O6--2'deoxyguanosine derivatives yields cleaner DNA fragments by supressing side reactions.Modifications improving the phosphotriester methodology are presented.The purification methods and analysis of synthetic oligodeoxyribonucleotides are described.

Simplified Liquid-Phase Preparation of Four Decadeoxyribonucleotides and their Preliminary Spectroscopic Characterization

Four self-complementary decadeoxyribonucleotides, dApTpApTpApTpApTpApT,dApTpApTpCpGpApTpApT, dApTpApTpGpCpApTpApT and dApApApApApTpTpTpTpT, were chemically synthesized by the phosphotriester procedure.Efforts were concentrated on keeping the procedure as simple as possible, concomitant with obtaining high-purity products at each step of the process.The decamers were elaborated from the 3'-end, starting with a 3'-O-benzoylated monomer according to the scheme: monomer + monomer -> dimer + dimer -> tetramer + dimer -> hexamer + tetramer -> decamer.Putity of intermediates and of the fully blocked decamers were monitored by chromatography and by 300-MHz 1H-NMR. spectroscopy.The deblocked decadeoxyribonucleotides were characterized by their UV., CD., and 1H-NMR. spectra.