Einecs 286-938-3

Base Information

Chemical Name:Einecs 286-938-3
CAS No.:85393-37-9
Molecular Formula:C₆H₁₅N*C₃₇H₃₆ClN₂O₁₀P
Molecular Weight:836.319
Hs Code.:
European Community (EC) Number:286-938-3

Synonyms:EINECS 286-938-3;85393-37-9

Suppliers and Price of Einecs 286-938-3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Einecs 286-938-3

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:16
Exact Mass:835.3000595
Heavy Atom Count:58
Complexity:1270

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN(CC)CC.CC1=CN(C(=O)NC1=O)C2CC(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(=O)(O)OC6=CC=CC=C6Cl
Isomeric SMILES:CCN(CC)CC.CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(=O)(O)OC6=CC=CC=C6Cl

Technology Process of Einecs 286-938-3

There total 5 articles about Einecs 286-938-3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15715-58-9
triethylamine carbonate

: 72351-28-1
2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 85393-37-9
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide); 5'-O-(4-4'-dimethoxytrityl)thymidine; In 1,4-dioxane; at 20 ℃; for 1h;

With pyridine; water; In 1,4-dioxane;

triethylamine carbonate;

Reference yield:

: 15715-58-9
triethylamine carbonate

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 85393-37-9
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: 5'-O-(4-4'-dimethoxytrityl)thymidine; 2-chlorophenyl dichlorophosphate; With pyridine; 1,2,3-triazole; In dichloromethane; at 0 ℃; for 2.5h;

triethylamine carbonate; With water; In dichloromethane; Further stages.;
DOI:10.1080/15257770701426260

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 85393-37-9
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2,4-triazole; Et₃N; 1-methylimidazole / tetrahydrofuran / 0.17 h

2: H₂O / tetrahydrofuran

With 1,2,4-Triazole; 1-methyl-1H-imidazole; water; triethylamine; In tetrahydrofuran; 1: Condensation / 2: Hydrolysis;
DOI:10.1080/07328319908044627