854002-03-2Relevant academic research and scientific papers
Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life
Pike, Kurt G.,Allen, Joanne V.,Caulkett, Peter W.R.,Clarke, David S.,Donald, Craig S.,Fenwick, Mark L.,Johnson, Keith M.,Johnstone, Craig,McKerrecher, Darren,Rayner, John W.,Walker, Rolf P.,Wilson, Ingrid
, p. 3467 - 3470 (2011/06/24)
The continued optimization of a series of glucokinase activators is described, including attempts to understand the interplay between molecular structure and the composite parameter of unbound clearance. These studies resulted in the discovery of a new sc
BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS
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Page/Page column 24, (2010/02/12)
Compounds of Formula: (I); wherein: R1 is selected from: fluoro, chloro, C1-3alkyl and C1-3alkoxy; R2-X- is selected from: methyl, methoxymethyl and Formula: (X); n is 0,1 or 2; or a salt, pro-drug or solvate thereof are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.
