851885-39-7

Upstream product

• 54915-31-0 methyl 3-(benzyloxy)-5-hydroxybenzoate 
• 851885-41-1 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoic acid 
• 851885-42-2 methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate 
• 854001-84-6 methyl 6-[3-{(1S)-1-methyl-2-methoxy-ethoxy}-5-{3-methylphenoxy}phenylcarbonylamino]pyridine-3-carboxylate 
• 851885-40-0 methyl 6-[({3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate 

Downstream Products

• 855297-61-9 methyl 6-{[(3-[(2-cyclopentylideneethyl)oxy]-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}pyridine-3-carboxylate 
• 854269-47-9 methyl 6-{[(3-(1,3-benzodioxol-5-yloxy)-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}pyridine-3-carboxylate 
• 854269-44-6 methyl 6-{[(3-(2,3-dihydro-1,4-benzodioxin-6-yloxy)-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}pyridine-3-carboxylate 
• 855297-59-5 methyl 6-{[(3-[(2,2-difluoro-2-phenylethyl)oxy]-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}pyridine-3-carboxylate 
• 851884-94-1 methyl 6-{3-[(1S)-1-methyl-2-furan-2-ylethoxy]-5-[(1S)-2-methoxy-1-methylethoxy]-benzoylamino}-3-pyridine carboxylate 
• 1313195-19-5 C₂₆H₂₉N₃O₆ 
• 1313195-11-7 C₂₄H₂₄N₂O₇ 
• 1313195-12-8 C₂₃H₂₁ClN₂O₆ 
• 1313195-13-9 C₂₃H₂₁ClN₂O₆ 
• 1313195-14-0 C₂₅H₂₇N₃O₆ 
• 854002-06-5 C₂₅H₂₆N₂O₇ 
• 1313195-17-3 C₂₄H₂₃ClN₂O₆ 
• 1313195-18-4 C₂₄H₂₃ClN₂O₆ 
• 854002-03-2 C₂₄H₂₃FN₂O₆ 

Relevant academic research and scientific papers

Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life

The continued optimization of a series of glucokinase activators is described, including attempts to understand the interplay between molecular structure and the composite parameter of unbound clearance. These studies resulted in the discovery of a new sc

BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS

A compound of Formula (I): Formula (I) wherein: R1 is selected from hydrogen and C1-4alkyl; R2 is selected from: R4-C(R5aR5b)- , R4=C(R6)- and R7aC(R7b

BENZOYL AMINO PYRIDIL CARBOXYLIC ACID DERIVATIVES AS GLUOKINASE ACTIVATORS

Compounds of Formula (I) wherein: R1-X- is selected from: methyl, methoxymethyl and Formula (X); R2 is selected from hydrogen, methyl, chloro and fluoro; n is 1 or 2; or a salt, pro-drug or solvate thereof, are described. Their use a

PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS

A compound of Formula (I): wherein: A is phenyl or a 5- or 6-membered heteroaryl ring, optionally substituted; R1 and R2 are selected from hydrogen and methyl; with the proviso that at least one of R1 and R2 is

BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS

Compounds of Formula: (I); wherein: R1 is selected from: fluoro, chloro, C1-3alkyl and C1-3alkoxy; R2-X- is selected from: methyl, methoxymethyl and Formula: (X); n is 0,1 or 2; or a salt, pro-drug or solvate thereof are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.