854002-06-5Relevant academic research and scientific papers
Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life
Pike, Kurt G.,Allen, Joanne V.,Caulkett, Peter W.R.,Clarke, David S.,Donald, Craig S.,Fenwick, Mark L.,Johnson, Keith M.,Johnstone, Craig,McKerrecher, Darren,Rayner, John W.,Walker, Rolf P.,Wilson, Ingrid
, p. 3467 - 3470 (2011/06/24)
The continued optimization of a series of glucokinase activators is described, including attempts to understand the interplay between molecular structure and the composite parameter of unbound clearance. These studies resulted in the discovery of a new sc
