854263-73-3Relevant academic research and scientific papers
Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation
Zhao, Hongyu,Xin, Zhili,Liu, Gang,Schaefer, Verlyn G.,Falls, H. Douglas,Kaszubska, Wiweka,Collins, Christine A.,Sham, Hing L.
, p. 6655 - 6657 (2004)
A case study of rational design of an efficient, specific, and proprietary molecular scaffold based on the structure-activity relationship (SAR) information on a screening hit is described. Potent, selective, and orally bioavailable tetralin carboxamide g
