854443-33-7

Upstream product

• 854443-32-6 C₇₅H₉₃N₇O₁₁Si 
• 64-18-6 formic acid 

Downstream Products

• 854443-36-0 [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester 
• 854443-35-9 [(S)-4-{(5S,10S)-10-[(S)-1-Azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-5-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-5-oxo-pentyl]-carbamic acid allyl ester 
• 854443-34-8 Formic acid (S)-1-((S)-5-allyloxycarbonylamino-2-{(5S,10S)-10-[(S)-1-azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-pentanoyl)-pyrrolidin-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis of a β-turn mimetic suitable for incorporation in the peptide hormone LHRH

LHRH is a decapeptide hormone which plays a central role in neuroendocrinology. Conformational studies have suggested that LHRH may adopt a β-turn involving residues 5-8 when bound to its receptor. A β-turn mimetic with side chains corresponding to those of a Tyr-Gly-Leu-Orn tetrapeptide has therefore been synthesized for incorporation at positions 5-8 in LHRH. In the turn mimetic, residues i and i+1 are connected by a ψ[CH2O] isostere instead of an amide bond, while a covalent ethylene bridge replaces the hydrogen bond which is often found between residues i and i+3 in β-turns. The turn mimetic was assembled from three types of building blocks: an azido aldehyde, an Fmoc protected amino acid and a protected dipeptide amine.