[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

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Chemical Name:[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid
CAS No.:854443-33-7
Molecular Formula:C₅₆H₆₇N₇O₁₂
Molecular Weight:1030.19
Hs Code.:

[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

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Chemical Property of [(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

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Technology Process of [(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

There total 1 articles about [(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 854443-32-6
C₇₅H₉₃N₇O₁₁Si

: 64-18-6
formic acid

: 854443-33-7
[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

Guidance literature:: at 20 ℃; for 19h;
DOI:10.1016/j.tet.2005.03.061

Reference yield:

: 854443-33-7
[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 854443-36-0
[1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester

Guidance literature:: With (2-chloropropyl)dimethylamine hydrochloride; In ethyl acetate; at 0 ℃; for 1h;
DOI:10.1016/j.tet.2005.03.061

Reference yield:

: 854443-33-7
[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

: 854443-35-9
[(S)-4-{(5S,10S)-10-[(S)-1-Azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-5-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-5-oxo-pentyl]-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 115 mg / 2-dimethylaminoisopropyl chloride hydrochloride / ethyl acetate / 1 h / 0 °C

2: 39 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / dioxane / 3.5 h / Heating

3: LiOH / H₂O; tetrahydrofuran; methanol / 3.5 h / 0 - 20 °C

With lithium hydroxide; (2-chloropropyl)dimethylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/j.tet.2005.03.061