85446-60-2Relevant academic research and scientific papers
Reactivity models of 1-N-vinyluracil and synthesis of a new class of potential antiviral agents by the use of 1,3-dipolar cycloaddition reactions
Colacino,De Luca,Liguori,Napoli,Siciliano,Sindona
, p. 743 - 745 (2007/10/03)
By the use of a convergent approach based on 1,3-dipolar cycloaddition reactions between N-protected formylnitrones generated in situ and 1 -N-vinyluracil, a new class of 4′-aza-analogues of 2′,3′ -dideoxynucleosides is synthesized. Competitive reaction for the endocyclic bond of uracil also brings to a new isoxazolidine derivative fused with the pyrimidine nucleus.
Synthesis of acyclic analogs of pyrimidine nucleosides with aromatic units in the side chain
Novikov,Ozerov,Brel',Solodunova,Ozerova
, p. 328 - 332 (2007/10/03)
The synthesis of some pyrimidine acyclonucleotides with aromatic units in the side chain has been accomplished. Their physicochemical and spectroscopic properties have been studied. These compounds may be described as the substances with potential as antiviral and anticancer activity. 1996 Plenum Publishing Corporation.
Synthesis of aliphatic nucleoside analogues with potential antiviral activity
Colla,Busson,De Clercq,Vanderhaeghe
, p. 569 - 576 (2007/10/02)
The synthesis of a series of double-modified adenosine and 8-aza-adenosine analogues, altered in the 6-position of the base and having the sugar moiety replaced by an acyclic hydroxylated side chain is described. Also, some aliphatic derivatives of 5-iodo- and E-5-(2-bromovinyl)uracil were prepared. Of all these compounds, only 6-hydroxylamino-9-(2,3-dihydroxypropyl)purine displayed some antiviral activity when tested in primary rabbit kidney cell cultures against vesicular stomatitis, vaccinia or herpes simplex virus.
