78692-74-7

Basic information

• Product Name: 1-(2-HYDROXY-ETHOXYMETHYL)-5-IODO-1H-PYRIMIDINE-2,4-DIONE
• Synonyms: 1-(2-HYDROXY-ETHOXYMETHYL)-5-IODO-1H-PYRIMIDINE-2,4-DIONE
• CAS NO: 78692-74-7
• Molecular Formula: C₇H₉IN₂O₄
• Molecular Weight: 312.06183
• Mol File: 78692-74-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 2.05g/cm³
• Refractive Index: 1.661
• CAS DataBase Reference: 1-(2-HYDROXY-ETHOXYMETHYL)-5-IODO-1H-PYRIMIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-HYDROXY-ETHOXYMETHYL)-5-IODO-1H-PYRIMIDINE-2,4-DIONE(78692-74-7)
• EPA Substance Registry System: 1-(2-HYDROXY-ETHOXYMETHYL)-5-IODO-1H-PYRIMIDINE-2,4-DIONE(78692-74-7)

Safety Data

• Hazardous Substances Data: 78692-74-7(Hazardous Substances Data)

Usage

Chemical compound

Yes

Usage

Commonly used in biochemical and biomedical research

Derivative of

5-iodouracil

Function

Often used as a reagent for detecting proteins in biological samples

Solubility

Soluble in water and ethanol

Storage

Typically stored at room temperature

Molecular weight

353.07 g/mol

Safety precautions

Handle with care, as exposure can cause irritation to the skin and eyes

Importance

An important chemical tool in the field of biochemistry and biomedicine

InChI:InChI=1/C7H9IN2O4/c8-5-3-10(4-14-2-1-11)7(13)9-6(5)12/h3,11H,1-2,4H2,(H,9,12,13)

Upstream product

• 78097-04-8 1-[(2-hydroxyethoxy)methyl]uracil 
• 73366-61-7 <2-(trimethylsiloxy)ethoxy>methyl iodide 
• 696-07-1 5-iodouracil 
• 78096-99-8 Benzoic acid 2-(4-ethoxy-2-oxo-2H-pyrimidin-1-ylmethoxy)-ethyl ester 
• 78097-03-7 1-<<2-(benzoyloxy)ethoxy>methyl>uracil 
• 85446-60-2 1-(2-benzyloxyethoxymethyl)-uracil 
• 646-06-0 1,3-DIOXOLANE 
• 38953-72-9 5-iodo-2,4-bis-O-trimethylsilyluracil 
• 66818-26-6 1,3-bis-(trimethylsilyl)-5-iodouracil 
• 78097-08-2 1-<(2-acetoxyethoxy)methyl>-5-iodouracil 
• 80504-47-8 1,2-dihydro-5-iodo-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine 

Downstream Products

• 848609-24-5 1-(2-hydroxy-ethoxymethyl)-5-phenylethynyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis and biological evaluation of carbon-11-labeled acyclic and furo[2,3-d]pyrimidine derivatives of bicyclic nucleoside analogues (BCNAs) for structure-brain uptake relationship study of BCNA tracers

We reported earlier on radiolabeled alkoxyphenyl bicyclic nucleoside analogues (BCNAs) as potential positron emission tomography (PET) reporter probes for imaging of varicella zoster virus thymidine kinase (VZV-tk) gene in vivo. Despite their favorable ph

A convenient one-pot synthesis of acyclonucleosides

Bis(trimethylsilyl)pyrimidine bases were treated directly with 1,3-dioxolane (or 2-methyl-1,3-dioxolane), chlorotrimethylsilane and a metal iodide, such as KI or NaI, in acetonitrile at room temperature to afford acyclopyrimidine derivatives, including 2-thiopyrimidine derivatives, in good yields. Introduction of an acyclic chain into 2-thiopyrimidine bases, however, necessitated the use of 2 eq of the reagents.

Nucleic acid related compounds. 37. Convenient and high-yield syntheses of N-[(2-hydroxyethoxy)methyl] heterocycles as 'acyclic nucleoside' analogues

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