85453-99-2

Upstream product

• 502-49-8 cycloactanone 
• 344886-32-4 3-Dimethylaminomethyl-3,4-dihydro-2H-quinolin-1-ylamine 
• 84741-86-6 quinoline-3-carbonyl chloride 
• 6480-68-8 quinoline-3-carboxylic acid 
• 25283-63-0 N,N-dimethylquinoline-3-carboxamide 
• 344444-05-9 1-Nitroso-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid dimethylamide 
• 177202-66-3 1,2,3,4-tetrahydroquinoline-3(R,S)-carboxylic acid (N,N-dimethyl)amide 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of some tetracyclic indole derivatives

Several related series of cycloalkyl[4,5]pyrrolo[3,2,1-ij]quinolines 7a-g, 8a-c, 10a-e, and 16a-f and indolo[3,2,1-hi]indoles 22a-c and 23a,b were synthesized and tested for anticonvulsant activity. The key preparative step, a Fischer indole reaction between a bicyclic hydrazine and a cyclic ketone, gave the compounds in 34-96% yield. The products were tested in rat maximal electroshock for anticonvulsant activity. Several compounds showed good activity, with 6-[(dimethylamino)methyl]-4,5,6,8,9,10-hexahydrocyclopenta[4,5]pyrrolo[3,2 ,1-ij]quinoline (7d) and N-methyl-4,5,6,8,9,10,11,12-octahydrocyclohepta[4,5]pyrrolo[3,2,1-ij]quino line-6-carboxamide (10c) having ED50's of 12.5 and 12.9 mg/kg po, respectively.