85455-25-0Relevant academic research and scientific papers
7&α- or 7&β-(4-Phenylbutyl)dihydrocodeine Derivatives
Leland, David L.,Kotick, Michael P.
, p. 1813 - 1819 (2007/10/02)
A lipophilic 4-phenylbutyl group was selectively incorporated into the 7α- or 7β-position of the morphine nucleus by use of 6,7-oxymethylene (oxetane) intermediates. 7,7-Bisdihydroisocodeine (2) with dilute NaOH gave 6β,7β-(oxymethylene)
Analgesic narcotic antagonists. XV. Potent narcotic agonist 7β-(arylalkyl)-4,5α-epoxymorphinans
Kotick,Leland,Polazzi,Howes,Bousquet
, p. 1050 - 1056 (2007/10/02)
Structure-activity correlations in 7β-(arylalkyl)-3-methoxy- or -hydroxy-4,5α-epoxymorphinans have been investigated. 6β-Hydroxy-7α-hydroxymethyl compounds 7 with 7β-substituents CH2CH2R [a, R = H; b, R = CH2CH3
