85455-01-2

Upstream product

• 85455-00-1 7,7-bis<(tosyloxy)methyl>-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one 
• 77794-00-4 7,7-bis<(tosyloxy)methyl>-4,5α-epoxy-3-methoxy-17-methylmorphinan-6β-ol 

Downstream Products

• 85455-09-0 7α,17-dimethyl-4,5α-epoxy-3-methoxy-7β-(4-phenylbutyl)morphinan-6α-ol 
• 85455-25-0 C₂₈H₃₄BrNO₃ 
• 85455-08-9 4,5α-epoxy-17-methyl-7β-(4-phenylbutyl)-6α,7α-(oxymethylene)morphinan-3-ol 
• 85455-07-8 4,5α-epoxy-3-methoxy-17-methyl-7β-(4-phenylbutyl)-6α,7α-(oxymethylene)morphinan 
• 85455-10-3 7α,17-dimethyl-4,5α-epoxy-3-methoxy-7β-(4-phenylbutyl)morphinan-6-one 
• 85455-06-7 4,5α-epoxy-3-methoxy-17-methyl-7β-(4-phenyl-1,3-butadienyl)-6α,7α-(oxymethylene)morphinan 
• 85455-02-3 4,5α-epoxy-3-methoxy-17-methyl-7β-<(tosyloxy)methyl>-6β,7β-(oxymethylene)morphinan 

Relevant academic research and scientific papers

7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans

Disclosed are 7β-arylalkyl substituted morphinan compounds characterized by the formula: STR1 In the above formula, R is H or methyl, R1 is methyl, cyclopropylmethyl or cyclobutylmethyl and n is 2 to 5.

7&α- or 7&β-(4-Phenylbutyl)dihydrocodeine Derivatives

A lipophilic 4-phenylbutyl group was selectively incorporated into the 7α- or 7β-position of the morphine nucleus by use of 6,7-oxymethylene (oxetane) intermediates. 7,7-Bisdihydroisocodeine (2) with dilute NaOH gave 6β,7β-(oxymethylene)