85460-28-2Relevant academic research and scientific papers
Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates
Zhang, Huijie,Lv, Kaikai,Ma, Lanping,Zhang, Yongliang,Yu, Ting,Chen, Lin,Wang, Xin,Shen, Jingkang,Meng, Tao
supporting information, (2020/04/28)
A one-step synthesis of novel functionalized 3,4-dihydro-2H-pyrroles from 2-isocyanoacetates and readily synthesized acrylonitriles is reported. The reaction proceeds smoothly under mild conditions with high efficiency. The structures of two representativ
Magnetic nanoparticle supported amine: An efficient and environmental benign catalyst for versatile Knoevenagel condensation under ultrasound irradiation
Ying, Anguo,Wang, Limin,Qiu, Fangli,Hu, Huanan,Yang, Jianguo
, p. 223 - 232 (2015/03/04)
Amine functionalized silica coated Fe3O4 nanoparticles (SiO2@MNP-A) were successfully prepared as a novel heterogeneous amine. The catalyst was characterized by XRD, FT-IR, TEM, magnetic measurement, elemental analysis and was found to be a magnetically separable and highly active catalyst for ambient Knoevenagel condensation of aromatic aldehydes and a-aromatic (heteroaromatic or polyaromatic)-substituted methylene compounds in water under ultrasonic irradiation to afford the corresponding products in good to excellent yields. Very interestingly, SiO2@MNP-A successfully catalyze the reaction of the non-cyano substituted compound with benzaldehyde to achieve a key intermediate for the preparation of Atorvastatin calcium in green and atom-economic manner. In addition, the catalyst SiO2@MNP-A can be reused for 8 times without any obvious loss of its activity. The role of ultrasonication in the Knoevenagel condensation was also discussed with the assistance of UV-vis spectrometry.
Knoevenagel condensation reaction using ionic liquid [ADPQ][CF3SO3] as green and reusable catalyst
Gao, Xiaochong,Gao, Can,Gao, Ruichang
, p. 2145 - 2148 (2015/11/28)
Knoevenagel condensation reaction of aromatic aldehydes with some active methylene compounds proceeded efficiently without solvent using ionic liquids as catalyst. The experimental results show that these ionic liquids have good catalytic activities to th
Microwave-Assisted synthesis under solvent-free conditions of (E)-2-(Benzo[d]thiazol-2-yl)-3-arylacrylonitriles
Trilleras, Jorge E.,Velasquez, Kelly J.,Pacheco, Dency J.,Quiroga, Jairo,Orti?z, Alejandro
experimental part, p. 2396 - 2402 (2012/03/08)
A series of (E)-2-(benzo[d]thiazol-2-yl)-3-arylacrylonitriles was synthesized by microwave assisted Knoevenagel condensation under solvent-free conditions from the corresponding 2-(benzo[d]thiazol-2-yl)acetonitrile and aromatic aldehydes with electrondona
UNCATALYZED KNOEVENAGEL CONDENSATION OF 2-CYANOMETHYLBENZOTHIAZOLE WITH AROMATIC ALDEHYDES. PREPARATION OF 3-ARYL-2-(2-BENZOTHIAZOLYL)-ACRYLONITRILES AND 3-(2-BENZOTHIAZOLYL)-COUMARIN IMINES
Dryanska, Veneta
, p. 325 - 329 (2007/10/02)
A series of 3-aryl-2-(2-benzothiazolyl)-acrylonitriles (3a-n) and 3-(2-benzothiazolyl)-coumarin imines (5a-f) are prepared in good to high yields by refluxing solutions of 2-cyanomethylbenzothiazole (1) and aromatic aldehydes (2, 4) in ethanol. Key words:
Electro-organic Synthesis of some Cyclopentanone Derivatives
Azzem, Magdi A.,Elgemeie, Gald E. H.,Neguid, Mohamed A.,Fahmy, Hussein M.,Elmassry, Zakeya
, p. 545 - 550 (2007/10/02)
The electroreduction of some benzothiazole derivatives in aqueous media has been studied.A mechanism is suggested and discussed for the formation of the cyclopentanone derivatives which were isolated and identified.The mechanism proposed has been confirme
Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyridobenzothiazoles and 1,3-Benzothiazole Derivatives
Fathy, N. M.,Motti, F. M. Abdel,Elgemeie, G. E. H.
, p. 509 - 512 (2007/10/02)
Novel synthesis of pyridobenzothiazoles, pyridine, pyran, thiopyran, pyridazine and coumarin derivatives utilising benzothiazol-2-ylacetonitrile, as starting component are reported.
