854638-56-5

Basic information

• Product Name: tert-butyl 6-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate
• Synonyms: tert-butyl 6-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate
• CAS NO: 854638-56-5
• Molecular Formula: C19H29NO3Si
• Molecular Weight: 347.52396
• Mol File: 854638-56-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 6-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate(854638-56-5)
• EPA Substance Registry System: tert-butyl 6-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate(854638-56-5)

Safety Data

• Hazardous Substances Data: 854638-56-5(Hazardous Substances Data)

Upstream product

• 2380-86-1 6-hydroxy-1H-indole 
• 34619-03-9 tert-butyldicarbonate 
• 106792-41-0 6-<<(2,2-dimethylethyl)dimethylsilyl>oxy>indole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 848357-99-3 6-(tert-butyldimethylsilanyloxy)indole-1-carboxylic acid tert-butyl ester 2-boronic acid 
• 870098-73-0 6-(tert-butyldimethylsiloxymethyl)-2-[6-(4-hydroxy-3,5-dimethyl-phenyl)-3-methoxy-pyridazin-4-yl]-indole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Optimisation of ITK inhibitors through successive iterative design cycles

Based on a hit cluster of compounds inhibiting interleukin-2 inducible T-cell kinase (ITK) in the submicromolar range a series of ITK inhibitor libraries were synthesized. Through iterative design cycles including kinase crystal structure information, indolylindazole libraries were identified which showed low nanomolar activity in enzymatic and cellular assays. The potential of these novel lead series was confirmed through in vivo tests in an anti-CD3-IL2 mouse model. The intravenous administration of highly potent ITK inhibitor 11o resulted in dose-dependent, efficient suppression of IL-2.

Novel organophosphorus derivatives of indazoles and use thereof as medicinal products

The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.