854891-91-1

Basic information

• Product Name: 3',4'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE
• Synonyms: 3',4'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE;OTAVA-BB 1043874
• CAS NO: 854891-91-1
• Molecular Formula: C₁₁H₁₂Cl₂O
• Molecular Weight: 231.12
• Mol File: 854891-91-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 317.6°C at 760 mmHg
• Flash Point: 133.6°C
• Appearance: /
• Density: 1.188g/cm³
• Vapor Pressure: 0.000381mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 3',4'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE(854891-91-1)
• EPA Substance Registry System: 3',4'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE(854891-91-1)

Safety Data

• Hazardous Substances Data: 854891-91-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H12Cl2O/c1-11(2,3)10(14)7-4-5-8(12)9(13)6-7/h4-6H,1-3H3

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Relevant articles and documents

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

Herein we report the synthesis and evaluation of a series of thiosemicarbazones as potential inhibitors of cysteine proteases relevant to parasitic diseases. Derivatives of thiosemicarbazone 1 were discovered to be potent inhibitors of cruzain and rhodesain, crucial proteases in the life cycles of Trypanosoma cruzi and T. brucei rhodesiense, the organisms causing Chagas' disease and sleeping sickness. However, the entire series had only modest potency against falcipain-2, an essential protease for Plasmodium falciparum, the organism causing malaria. Among the active inhibitors, several potently inhibited proliferation of cultures of T. brucei. However, only modest activity was observed in inhibition of proliferation of T. cruzi or P. falciparum. Herein we report the synthesis and evaluation of a series of thiosemicarbazones as potential inhibitors of cysteine proteases relevant to parasitic diseases. Derivatives of thiosemicarbazone 1 were discovered to be potent inhibitors of cruzain and rhodesain, crucial proteases in the life cycles of Trypanosoma cruzi and T. brucei rhodesiense, the organisms causing Chagas' disease and sleeping sickness. However, the entire series had only modest potency against falcipain-2, an essential protease for Plasmodium falciparum, the organism causing malaria. Among the active inhibitors, several potently inhibited proliferation of cultures of T. brucei. However, only modest activity was observed in inhibition of proliferation of T. cruzi or P. falciparum.