854920-11-9

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 41904-39-6 3-chloro-benzeneacetyl chloride 
• 766-80-3 1-bromomethyl-3-chlorobenzene 
• 624-49-7 dimethylfumarate 
• 456-39-3 3-chlorobenzenediazonium tetrafluoroborate 
• 617-52-7 Dimethyl itakonate 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 587-04-2 m-Chlorobenzaldehyde 
• 106-65-0 Dimethyl succinate 

Downstream Products

• 79219-90-2 2-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-3-cyclohexylidene-succinic acid 4-methyl ester 
• 1459222-13-9 2-(E)-(3-chlorophenyl)methylidenesuccinic acid 
• 79219-91-3 2-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-3-cyclohexylidene-succinic acid 

Relevant academic research and scientific papers

Phosphine-Catalyzed Cross-Coupling of Benzyl Halides and Fumarates

A phosphine-catalyzed olefinic cross-coupling between benzyl halides and fumarates is described, which affords trisubstituted alkenes in good yields and excellent E-selectivity under metal-free conditions. Mechanistic studies suggest a catalytic cycle involving phosphorus ylide formation, Michael addition, water-assisted hydrogen transfer, and phosphine elimination.

Benign Arylations of Dimethyl Itaconate via Heck–Matsuda Reaction Utilizing in-Situ Generated Palladium on Aluminum Oxide

In situ generated palladium on aluminum oxide provides an active and efficient catalytic system for the preparation of arylmethylidene succinates using the Heck–Matsuda reaction. Beside the monoarylation the first examples of the biarylation of these mono

Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase

A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent,

Unexpected reaction of dimethyl acetylenedicarboxylate with in situ generated arylketenes catalyzed by 1-methylimidazole

(Chemical Equation Presented) An unexpected 1-methylimidazole-catalyzed reaction of dimethyl acetylenedicarboxylate (DMAD) with in situ generated arylketenes leading to the synthesis of dimethyl 2-arylidenesuccinates under mild conditions is described. A plausible mechanism has been proposed.