854931-17-2

Upstream product

• 154674-77-8 2-Methylpropyl (R)-2-(benzyloxymethoxy)propanoate 
• 155433-60-6 (3R,4R)-4-((benzyloxy)methoxy)-3-((4-methoxybenzyl)oxy)pentanal 
• 159572-27-7 (R)-2-((benzyloxy)methoxy)propanal 
• 854931-16-1 (8S,10R,11R)-11-Benzyloxymethoxy-8-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-3,3-dimethyl-dodec-1-en-4-one 
• 854931-27-4 (8S,10R,11R)-11-Benzyloxymethoxy-8-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-3,3-dimethyl-dodec-1-en-4-ol 
• 854931-15-0 (5S,7R,8R)-8-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-nonanal 
• 854931-14-9 {1-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyloxy}-tert-butyl-dimethyl-silane 

Downstream Products

• 854931-18-3 (2S,6S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-(1,1-dimethyl-allyl)-2-methoxy-dihydro-pyran-3-one 

Relevant academic research and scientific papers

Synthetic studies on the bryostatins: Preparation of a truncated BC-ring intermediate by pyran annulation

(Chemical Equation Presented) A synthesis of a potential BC-ring subunit (C9-C27) for bryostatin 1, a remarkably potent anticancer agent, has been developed in 16 steps and 18% overall yield. The key features of this route include a BITIP-catalyzed asymmetric allylation reaction, chelation-controlled allylations, a hydroformylation reaction, and a pyran annulation reaction.