855162-94-6Relevant academic research and scientific papers
Concise, efficient and practical assembly of bromo-5,6-dimethoxyindole building blocks
Huleatt, Paul B.,Lau, Jacelyn,Chua, Sheena,Tan, Yun Lei,Duong, Hung Anh,Chai, Christina L.L.
experimental part, p. 1339 - 1342 (2011/03/22)
A concise, efficient and simple route to a series of bromoindole building blocks is described. The synthetic routes are highlighted by purification-free preparation of o-nitrocinnamate intermediates and clean, modified Cadogan indole syntheses. The scope of this indole synthesis has been explored and expanded through the use of a range of solvents and easily removable phosphine reagents.
An efficient route to xanthine based A2A adenosine receptor antagonists and functional derivatives
Labeaume, Paul,Dong, Ma,Sitkovsky, Michail,Jones, Elizabeth V.,Thomas, Rhiannon,Sadler, Sara,Kallmerten, Amy E.,Jones, Graham B.
supporting information; experimental part, p. 4155 - 4157 (2010/10/21)
A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. Yields are good and the process applicable to a range of substrates including a family of A2A adenosine receptor antagonists. A new route to the KW-6002 family of antagonists is presented including a pro-drug variant, and application to related image contrast agents developed.
