New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond

Article abstract of DOI:10.1016/S0040-4020(01)91346-8

α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh₃)₄ in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of -alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.