855473-48-2

Upstream product

• 181139-72-0 methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate 
• 10387-40-3 potassium thioacetate 
• 906107-36-6 Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate 
• 507-09-5 tiolacetic acid 

Downstream Products

• 855473-51-7 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester 
• 855473-49-3 C₂₉H₂₈ClNOS 
• 937389-18-9 C₃₀H₂₆ClNO₃S*ClH 
• 937275-17-7 C₇H₈O₃S*C₃₀H₂₆ClNO₃S 

Relevant academic research and scientific papers

Efficient synthesis for the preparation of montelukast

The present invention describes the improved process for the preparation of montelukast acid and its pharmaceutically acceptable salts and esters. The process is cost effective, environment friendly, and easily scale up to commercial level.

EFFICIENT SYNTHESIS FOR THE PREPARATION OF MONTELUKAST AND NOVEL CRYSTALLINE FORM OF INTERMEDIATES THEREIN

The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.

PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR

A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: (1) using a compound of formula (11) is provided.

Process for making montelukast and intermediates therefor

A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (20) is provided.