855594-74-0

Upstream product

• 53267-93-9 O-methyl-N-tert-butoxycarbonyl-L-tyrosine 
• 20989-19-9 (2S)-2-amino-3-(4-methoxyphenyl)propan-1-ol 
• 105-58-8 Diethyl carbonate 
• 126395-29-7 [(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 

Downstream Products

• 1002352-82-0 3-[1-(1H-1,2,3-benzotriazol-1-yl)butyl]-4-(4-methoxybenzyl)-1,3-oxazolidin-2-one 
• 1002352-65-9 (4S)-4-(4-methoxybenzyl)-3-[(2E)-2-methyl-1-(phenylsulfonyl)but-2-enyl]-1,3-oxazolidin-2-one 
• 1002352-66-0 (4S)-3-[2-(benzyloxy)-1-(phenylsulfonyl)ethyl]-4-(4-methoxybenzyl)-1,3-oxazolidin-2-one 
• 1002352-62-6 (4S)-4-(4-methoxybenzyl)-3-[1-(phenylsulfonyl)butyl]-1,3-oxazolidin-2-one 
• 1002352-64-8 (4S)-4-(4-methoxybenzyl)-3-[2-methyl-1-(phenylsulfonyl)propyl]-1,3-oxazolidin-2-one 
• 872692-55-2 Benzotriazol-1-yl-[(S)-4-(4-methoxy-benzyl)-2-oxo-oxazolidin-3-yl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Nitrogen (oxygen) heterocyclic pentane - 2 - one (thione) compound, pharmaceutical composition, preparation method and use thereof

The invention belongs to the field of pharmacology, and relates to aza (oxa)-cyclopentane-2- ketone (thione) compounds shown in the formula I, medicine compositions thereof, a preparation method, applications in preparation of medicines treating diabetes and glucolipid metabolism, and especially applications in preparation of medicines treating II-type diabetes.

NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS FOR TREATING NEUROPSYCHIATRIC DISORDERS

The present invention concerns benzodioxane-piperidine with general formula I: wherein notably: R1 represents one or more identical or different substituent(s) on the benzene ring, each independently representing a hydrogen or halogen atom, or a C1-4 alkyl group, or a C1-4 alkoxy group or a C1-4 hydroxyalkyl group or a C1-4 alkylcarbonyl or an alkoxycarbonyl group or an OH group or an SO2R group with R alkyl, or a CN group, or a CF3 group, or an OCF 3 group; n=1, 2 or 3;m=0 or 1, andR2 represents one or more identical or different substituent(s) on the oxazolidinone or morpholinone ring, each independently representing: a hydrogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group, or a C1-4 hydroxyalkyl group, or an alkylcarbonyl group, or an alkoxycarbonyl group, or an alkoxyphenyl group.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and componnds and compositions etc. for their treatment

Further studies on a samarium diiodide-promoted reductive carbon-nitrogen bond cleavage rection: Synthesis of (+)-aphanorphine

Samarium diiodide-promoted carbon-nitrogen bond cleavage reaction was applied to the 1,2,3,4-tetrahydroisoquinoline derivatives bearing an ester group at the 1- or 3-position to give the corresponding benzazepinones. Synthesis of (+)-aphanorphine was esta

Synthesis of tyrosine-derived tetrahydroisoquinolines by Lewis acid catalyzed cyclization of N-(phenylsulfonyl)alkyloxazolidinones

N-Boc-protected tyrosine esters 5a,b were converted into tetrahydroisoquinolines 13 and 14 in four steps by reduction and ring closure to oxazolidinones 9 and 10, addition of benzenesulfinic acid and aldehydes to sulfones 11 and 12 and subsequent Lewis ac

NOVEL INTERMEDIATES FOR THE SYNTHESIS OF (R)-TAMSULOSIN AND OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THEIR PREPARATION

A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

Enantioselective synthesis of (+)-aphanorphine by means of samarium diiodide promoted reductive carbon-nitrogen bond-cleavage reaction

An enantioselective synthesis of (+)-aphanorphine has been achieved by application of a samarium diiodide promoted reductive carbon-nitrogen bond-cleavage reaction to a 1-methoxy-carbonyl-1,2,3,4-tetrahydroisoquinoline providing a benzazepinone derivative