855662-14-5Relevant academic research and scientific papers
Synthesis of 12- O-Mono- and Diglycosyl-oxystearates, a New Class of Agonists for the C-type Lectin Receptor Mincle
Van Huy, Le,Tanaka, Chiaki,Imai, Takashi,Yamasaki, Sho,Miyamoto, Tomofumi
, p. 44 - 49 (2019)
Fifteen glycosyl-oxystearates were synthesized by Crich's 4,6-benzylidene and K?ening-Knorr strategies. Assessment of structure-activity relationships using macrophage-inducible C-type lectin (Mincle) receptor cells expressing nuclear factor of activated
A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins
Chae, Pil Seok,Rasmussen, S?ren G. F.,Rana, Rohini R.,Gotfryd, Kamil,Kruse, Andrew C.,Manglik, Aashish,Cho, Kyung Ho,Nurva, Shailika,Gether, Ulrik,Guan, Lan,Loland, Claus J.,Byrne, Bernadette,Kobilka, Brian K.,Gellman, Samuel H.
, p. 9485 - 9490 (2012)
Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, glyco-diosgenin (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM). Copyright
