85571-52-4Relevant academic research and scientific papers
Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines
Xue, Dengqi,Xue, Yijie,Yu, Haihua,Shao, Liming
supporting information, p. 874 - 884 (2019/02/10)
A metal-free radical cyclization reaction of vinyl isocyanides with alkanes is developed, allowing convenient access to a diverse range of potentially valuable 1-alkylisoquinolines. The methodology is simple and efficient, demonstrating excellent functional group tolerance and broad substrate scope. A mechanism involving a radical process is supported by kinetic isotope effect and radical inhibition studies.
Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts
Jiang, Heng,Cheng, Yuanzheng,Wang, Ruzhi,Zhang, Yan,Yu, Shouyun
, p. 6164 - 6167 (2014/06/09)
A synthetic strategy for multi-substituted isoquinoline derivatives has been developed using visible light-promoted vinyl isocyanide insertion with diaryliodonium salts at room temperature. The methodology presented here represents the first example of is
Syntheses of α-Alkylated β,γ-Unsaturated α-Amino Acids
Nunami, Ken-Ichi,Suzuki, Mamoru,Yoneda, Naoto
, p. 4015 - 4024 (2007/10/02)
Various α-alkylated β,γ-unsaturated α-amino acids were synthesized by the deconjugative alkylation of methyl α-isocyanoalkylidenesacetates followed by hydrolysis.In the mechanistic study, no marked differences in reactivity of geometrical isomers of methy
